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Combivir
Combivir
Active Ingredient: lamivudine zidovudine
Combivir is an antiviral medication containing a combination of lamivudine and zidovudine. These medicines are in a group of human immunodeficiency virus (HIV) medicines called reverse transcriptase inhibitors. Combivir helps keep the HIV virus from reproducing in the body.
Combivir 150mg
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150mg × 30 pills $6.64$199.2+ Cialis 

INDICATIONS

Combivir is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). This medication is not a cure for HIV or AIDS.

INSTRUCTIONS

Take Combivir exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Combivir can be taken with or without food.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Combivir can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly.

If you have hepatitis B you may develop liver symptoms after you stop taking Combivir, even months after stopping. Your doctor may want to check your liver function for several months after you stop using Combivir. Visit your doctor regularly.

If you missed a dose - take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

DOSAGE

Adults and Adolescents Weighing ≥ 30 kg

The recommended oral dose of COMBIVIR in HIV-1-infected adults and adolescents weighing greater than or equal to 30 kg is 1 tablet (containing 150 mg of lamivudine and 300 mg of zidovudine) twice daily.


Pediatric Patients

The recommended oral dosage of scored COMBIVIR Tablets for pediatric patients who weigh greater than or equal to 30 kg and for whom a solid oral dosage form is appropriate is 1 tablet administered twice daily.

Before prescribing COMBIVIR Tablets, children should be assessed for the ability to swallow tablets. If a child is unable to reliably swallow a COMBIVIR tablet, the liquid oral formulations should be prescribed: EPIVIR® (lamivudine) Oral Solution and


Patients Requiring Dosage Adjustment

Because COMBIVIR is a fixed-dose combination tablet, it should not be prescribed for pediatric patients weighing less than 30 kg or patients requiring dosage adjustment, such as those with reduced renal function (creatinine clearance less than 50 mL/min), patients with hepatic impairment, or patients experiencing dose-limiting adverse reactions. Liquid and solid oral formulations of the individual components of COMBIVIR are available for these populations.

STORAGE 

Store this medicine at room temperature in a tightly-closed container, away from heat and light.

Do not use Combivir if you are allergic to lamivudine or zidovudine. Combivir (Combivir) should not be taken together with any other medications that contain either of the two drugs. This includes Epivir, Retrovir, Epzicom (abacavir and lamivudine), and Trizivir (abacavir, lamivudine, zidovudine).

To make sure you can safely take Combivir, tell your doctor if you have any of these other conditions:

  • kidney disease;
  • liver disease (including hepatitis);
  • pancreatitis;
  • bone marrow suppression; or
  • problems with your muscles.

Some people develop a life-threatening condition called lactic acidosis while taking Combivir. You may be more likely to develop lactic acidosis if you are overweight or have liver disease, if you are a woman, or if you have taken HIV or AIDS medications for a long time. Talk with your doctor about your individual risk.

FDA pregnancy category C. It is not known whether Combivir will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Combivir. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Combivir on the baby.

Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk. Do not give this medication to a child who weighs less than 66 pounds.

Combivir should not be taken together with any other medications that contain either of these two drugs. This includes Epivir, Retrovir, Epzicom (abacavir and lamivudine), and Trizivir (abacavir, lamivudine, zidovudine).

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Taking Combivir will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Get emergency medical help if you have any of these signs of an allergic reaction to Combivir: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Combivir may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as:

  • muscle pain or weakness;
  • numb or cold feeling in your arms and legs;
  • trouble breathing;
  • feeling dizzy, light-headed, tired, or very weak;
  • stomach pain, nausea with vomiting; or
  • slow or uneven heart rate.

Call your doctor at once if you have any of these other serious side effects:

  • fever, chills, body aches, flu symptoms;
  • pale skin, easy bruising or bleeding, unusual weakness;
  • trouble swallowing, trouble standing up or climbing stairs;
  • liver problems (stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes));
  • pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate); or
  • white patches or sores inside your mouth or on your lips.

Less serious Combivir side effects may include:

  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and trunk);
  • mild nausea, vomiting, diarrhea;
  • numbness or tingling;
  • sleep problems (insomnia);
  • headache, dizziness, tired feeling; or
  • cough, runny or stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

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